Application of in silico positional cloning and bioinformatic mutation analysis to the study of eye diseases.
Level V
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Abstract
A vast amount of DNA and protein sequence is now available and a plethora of programs have been developed to analyse the data. The bewildering variety of analyses that can be performed via the World-Wide Web can deter researchers from applying bioinformatics to augment their traditional genetic research. Focusing on the inherited eye diseases, this paper provides a guide to the appropriate software required for identification of candidate genes through to the detection and analysis of mutations.
Medical subject headings
- Cloning, Molecular
- Computational Biology
- DNA Mutational Analysis
- Eye Diseases
- Mutation