Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?
basic_science · Level V
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- Record sourced from PubMed, PMID 12007401.
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Abstract
Since the discovery of self-splicing RNAs, it has been suspected that the snRNAs are the catalytic components of the spliceosome. Recent evidence supports both the catalytic potential of the spliceosomal snRNAs and their resemblance to elements of group II introns.
Medical subject headings
- Catalytic Domain
- Magnesium
- RNA Splicing
- RNA, Small Nuclear
- Spliceosomes