The SWIB and the MDM2 domains are homologous and share a common fold.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 12016060.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of the MDM2 domain and that these two families of proteins may share a similar functional mechanism.
Medical subject headings
- Algorithms
- Chromosomal Proteins, Non-Histone
- Nuclear Proteins
- Proto-Oncogene Proteins
- Sequence Alignment
- Transcription Factors