Propofol reduces spinal motor neuron excitability in humans.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 12032032.
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Abstract
We investigated in humans whether changes in spinal motor neuron excitability correlate with the predicted propofol concentration (Cpt) achieved by a target-controlled infusion system. Propofol suppressed F-wave persistence in a Cpt-dependent manner, indicating that propofol depresses spinal motor neuron excitability at clinically relevant concentrations.
Medical subject headings
- Anesthesia, Intravenous
- Anesthetics, Intravenous
- Motor Neurons
- Neurosurgical Procedures
- Propofol
- Spinal Cord