Therapeutic uses of MAbs directed against CD20.

Abstract

There are two main classes of Abs directed against the CD20 Ag that have been developed for therapeutic intent: unconjugated and radio-labeled Abs. The clinical results available from the large clinical trials utilizing both the unconjugated and radiolabelled Abs are summarized in this article. Both of these classes of agents have shown promise in clinical trials both alone and in conjunction with conventional chemotherapy or high-dose chemotherapy and transplantation. Ongoing research with these agents will provide further evidence of the place in clinical practice for these agents.