A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.
basic_science · Level V
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- Also identified by PMC identifier 123077.
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Abstract
Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4-8 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTP is postsynaptically expressed, enhanced by chelating postsynaptic Ca(2+), and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.
Medical subject headings
- Cerebellum
- Cyclic AMP
- Egtazic Acid
- Excitatory Postsynaptic Potentials
- Long-Term Potentiation
- Nitric Oxide
- Nitroarginine