Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
basic_science · Level V
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Abstract
Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminately polyadenylate all mRNA, Cid13 is a cytoplasmic enzyme that specifically targets suc22 mRNA that encodes a subunit of ribonucleotide reductase (RNR). cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance.
Medical subject headings
- Cell Nucleus
- Cytoplasm
- DNA Replication
- DNA-Directed RNA Polymerases
- Eukaryotic Cells
- Nuclear Proteins
- Polynucleotide Adenylyltransferase
- RNA, Messenger
- Ribonucleotide Reductases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins