DMLE+: Bayesian linkage disequilibrium gene mapping.
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Abstract
The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies, and can incorporate prior information about gene location from an annotated human genome sequence. DMLE+ is available in both Windows GUI and portable UNIX command line versions at http://dmle.org.
Medical subject headings
- Chromosome Mapping
- Software