Visceral perception: inflammatory and non-inflammatory mediators.
review · Level V
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- Record sourced from PubMed, PMID 12077058.
- Also identified by PMC identifier 1867723.
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Abstract
Visceral hypersensitivity is currently the most widely accepted mechanism responsible for abdominal pain. Inflammatory mediators are known to sensitise primary afferents and to recruit silent nociceptors. Recent evidence suggests that non-inflammatory mediators also have the potential to trigger visceral pain. This sequence of events may constitute part of an alerting system which prompts the central nervous system to correct gastrointestinal responses to ingestion.
Medical subject headings
- Colonic Diseases, Functional
- Hyperalgesia
- Inflammation Mediators
- Nociceptors
- Sensation
- Visceral Afferents