Nail pigmentation caused by hydroxyurea: report of 9 cases.

Aste, Nicola; Fumo, Giuseppe; Contu, Franca; Aste, Natalia; Biggio, Pietro · J Am Acad Dermatol · 2002

case_report · Level V

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Abstract

We report a series of 9 patients, 6 men and 3 women, who presented nail hyperpigmentation arising between 6 and 24 months from the start of hydroxyurea therapy. The most commonly observed clinical pattern was that of longitudinal melanonychia. In only 1 patient, who was affected in all 20 nails, we observed longitudinal melanonychia, diffuse melanonychia, and hyperpigmentation of the skin.

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