Sex, AGility, and the regulation of alternative splicing.
basic_science · Level V
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Abstract
Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.
Medical subject headings
- Alternative Splicing
- Drosophila Proteins
- Eukaryotic Cells
- Gene Expression Regulation
- RNA, Messenger