Clathrin adaptors really adapt.
review · Level V
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- Record sourced from PubMed, PMID 12086597.
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Abstract
The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with the membrane and cytosolic tails of cargo proteins.
Medical subject headings
- Carrier Proteins
- Cell Membrane
- Clathrin
- Endocytosis
- Eukaryotic Cells
- Membrane Proteins
- Protein Transport