Expression of p63 and 14-3-3sigma in normal and hyperdifferentiated mucosa of the upper aerodigestive tract.
case_control · Level III
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Abstract
Our goal was to analyze p63 and 14-3-3sigma expression in normal and hyperdifferentiated head and neck mucosa. Compare the in vivo expression of p63 and 14-3-3sigma by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis. p63 is underexpressed and 14-3-3sigma is overexpressed in lichen planus on immunohistochemical analysis. The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14-3-3sigma plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14-3-3sigma, and mucosal differentiation. p63 and 14-3-3sigma may be molecular markers for oral lichen planus.
Medical subject headings
- Lichen Planus, Oral
- Membrane Proteins
- Phosphoproteins
- Precancerous Conditions
- Trans-Activators
- Tyrosine 3-Monooxygenase