The efficacy of lafutidine in improving preoperative gastric fluid property: a comparison with ranitidine and rabeprazole.
rct · Level II
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Abstract
Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that these variables were minimized with a single morning dose of lafutidine 20 mg compared with ranitidine or rabeprazole. Preoperative oral lafutidine may be an alternative to ranitidine as a prophylaxis against aspiration pneumonia.
Medical subject headings
- Acetamides
- Anti-Ulcer Agents
- Benzimidazoles
- Enzyme Inhibitors
- Gastric Acid
- Histamine H2 Antagonists
- Piperidines
- Preoperative Care
- Pyridines
- Ranitidine