Nature and nurture in vitamin B12 deficiency.

Zschocke, J; Schindler, S; Hoffmann, G F; Albani, M · Arch Dis Child · 2002

case_report · Level V

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Abstract

We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. Some patients with vitamin B12 deficiency may benefit from high dose folic acid supplementation, even if plasma concentrations are high.

Medical subject headings