Airway nitric oxide in Duchenne muscular dystrophy.
case_control · Level III
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- Record sourced from PubMed, PMID 12091865.
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Abstract
The expression of muscle membrane-associated neuronal nitric oxide synthase (NOS1) is significantly impaired in Duchenne muscular dystrophy. Mean (+/- SEM) exhaled NO in 13 male patients with Duchenne muscular dystrophy was significantly lower than in 11 healthy age-matched male control subjects (7.5 +/- 1.4 vs 16.6 +/- 3.2 parts per billion, P <.02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P <.001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children.
Medical subject headings
- Lung
- Muscular Dystrophy, Duchenne
- Nerve Tissue Proteins
- Nitric Oxide
- Nitric Oxide Synthase