Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia.
basic_science · Level V
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- Record sourced from PubMed, PMID 12097645.
- Also identified by PMC identifier 126639.
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Abstract
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.
Medical subject headings
- Arachidonate 12-Lipoxygenase
- Bradykinin
- Ganglia, Spinal
- Hyperalgesia
- Neurons
- Neurons, Afferent
- Pain
- Receptors, Bradykinin
- Receptors, Drug
- Signal Transduction