Histone methylation: dynamic or static?

Bannister, Andrew J; Schneider, Robert; Kouzarides, Tony · Cell · 2002

review · Level V

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Abstract

Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?

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