High headache prevalence among women with hemochromatosis: the Nord-Trøndelag health study.
cross_sectional · Level IV
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Abstract
In this large cross-sectional population-based study, 51,272 persons responded to a headache questionnaire and were screened for hemochromatosis. Phenotypic hemochromatosis and the C282Y/C282Y genotype were both associated with an 80% increase in headache prevalence evident only among women. The reason for this association is unclear, but one may speculate that iron overload alters the threshold for triggering a headache by disturbing neuronal function.
Medical subject headings
- Headache
- Hemochromatosis