Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma.
case_series · Level IV
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Abstract
Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.
Medical subject headings
- Autoantibodies
- Carcinoma, Small Cell
- Chorea
- Lung Neoplasms
- Nerve Tissue Proteins
- Paraneoplastic Syndromes, Nervous System