Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy.
prospective_cohort · Level II
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Abstract
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.
Medical subject headings
- Epilepsy, Temporal Lobe
- Hippocampus
- Seizures