DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.
case_series · Level IV
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Abstract
To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. DNA hypermethylation and LOH at the D17S5 locus were detected in six (18%) and 17 (52%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.
Medical subject headings
- Carcinoma, Transitional Cell
- DNA Methylation
- Kidney Neoplasms
- Urinary Bladder Neoplasms