Increased serum levels of the interferon-gamma-inducing cytokine interleukin-18 in myasthenia gravis.
cross_sectional · Level IV
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Abstract
In this study, the authors show that MG as an autoantibody-mediated disorder of neuromuscular transmission is associated with elevated serum levels of the interferon-gamma-inducing cytokine interleukin (IL)-18. IL-18 levels were higher in generalized than in ocular myasthenia and tended to decrease on clinical improvement. These findings suggest an unexpected role of IL-18 in B-cell-mediated autoimmune disease.
Medical subject headings
- Interferon-gamma
- Interleukin-18
- Myasthenia Gravis