Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response.
case_report · Level V
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Abstract
We describe the clinical and serological followup of a 9-year-old girl with anti-nucleolar organizing region 90/human upstream-binding factor (anti-NOR 90/hUBF) who had features of systemic sclerosis over a period of 17 years, from childhood into adulthood. We review the associations of anti-UBF autoantibodies, and provide evidence that anti-NOR 90/UBF immune response is antigen driven.
Medical subject headings
- Autoantibodies
- Autoantigens
- Nucleolus Organizer Region
- Pol1 Transcription Initiation Complex Proteins
- Scleroderma, Systemic