Genetic association studies: design, analysis and interpretation.
review · Level V
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- Record sourced from PubMed, PMID 12139434.
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Abstract
This paper provides a review of the design and analysis of genetic association studies. In case control studies, the different contingency tables and their relationships to the underlying genetic model are defined. Population stratification is discussed, with suggested methods to identify and correct for the effect. The transmission disequilibrium test is provided as an alternative family-based test, which is robust to population stratification. The relative benefits of each analysis are summarised.
Medical subject headings
- Case-Control Studies
- Genetic Techniques
- Linkage Disequilibrium
- Research Design