The effect of fluoride and hypothermia on the in vitro metabolism of mivacurium.
basic_science · Level V
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Abstract
The fluoride inhibition of mivacurium hydrolysis by pseudocholinesterase increases in hypothermia, but it will very rarely occur in clinical practice because it requires rather large fluoride concentrations (>50 micromol/L) and very low temperatures (<28 degrees C).
Medical subject headings
- Fluorides
- Hypothermia, Induced
- Isoquinolines
- Neuromuscular Nondepolarizing Agents