The role of beta-amyloid in Alzheimer's disease.
review · Level V
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Abstract
The current understanding of the role of amyloid in AD has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiologic genetics. Although the precise etiology of AD still remains poorly understood, the identification of the key biochemical players in the A beta generation (APP, PS-1 and -2, and BACE), and the development of transgenic models exhibiting progressive disease pathology, provide a strong framework on which to build a better understanding of the molecular events that lead to progressive neurodegeneration in AD.
Medical subject headings
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor