A new trigger for T cells.
review · Level V
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- Record sourced from PubMed, PMID 12176315.
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Abstract
Understanding the early events in T cell activation and signaling is an active area of research. A recent study has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck.
Medical subject headings
- CD3 Complex
- Immune System
- Lymphocyte Activation
- Oncogene Proteins
- Receptors, Antigen, T-Cell
- T-Lymphocytes