Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study.
basic_science · Level V
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Abstract
Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D(1) receptor and D(2) receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.
Medical subject headings
- Carrier Proteins
- Dopamine
- Dystonia Musculorum Deformans
- Molecular Chaperones
- Nerve Tissue Proteins
- Neuropeptides