Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 12196669.
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Abstract
Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.
Medical subject headings
- Carrier Proteins
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- Restless Legs Syndrome