How acute promyelocytic leukaemia revived arsenic.

Zhu, Jun; Chen, Zhu; Lallemand-Breitenbach, Valérie; de Thé, Hugues · Nat Rev Cancer · 2002

review · Level V

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Abstract

Despite its many therapeutic qualities, arsenic trioxide has been more commonly remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic trioxide to treat acute promyelocytic leukaemia has radically changed this view, providing new insights into the pathogenesis of this malignancy and raising hopes that arsenicals might be useful in treating other cancers.

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