Progressive loss of cardiac sympathetic innervation in Parkinson's disease.
case_series · Level IV
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- Record sourced from PubMed, PMID 12210793.
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Abstract
This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6-[(18)F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6-[(18)F]fluorodopamine-derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism.
Medical subject headings
- Dopamine
- Heart Conduction System
- Parkinson Disease
- Sympathetic Nervous System