Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome.
case_report · Level V
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Abstract
Ross syndrome consists of segmental hyperhidrosis with widespread anhidrosis, Adie syndrome, and areflexia. The cause of this disorder is unknown. Selective degeneration of cholinergic fibers or of neural crest-derived structures has been suggested. We present clinical and skin biopsy data of 4 patients, providing evidence of reduced cholinergic sweat gland innervation in hypohidrotic skin by morphometric analysis. These findings indicate a selective degenerative process of the cholinergic sudomotor neurons.
Medical subject headings
- Cholinergic Fibers
- Hyperhidrosis
- Hypohidrosis
- Pupil Disorders
- Reflex, Abnormal
- Sweat Glands