Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants.

Hogeveen, Marije; Blom, Henk J; Van Amerongen, Marjolein; Boogmans, Bas; Van Beynum, Ingrid M; Van De Bor, Margot · J Pediatr · 2002

case_control · Level III

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Abstract

We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 micromol/L). The odds ratio for neonatal stroke was 3.95 (95" CI 1.53-10.16) at the 80" cutoff level.

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