Central precocious puberty in girls with Williams syndrome.

Partsch, Carl-Joachim; Japing, Insa; Siebert, Reiner; Gosch, Angela; Wessel, Armin; Sippell, Wolfgang G; Pankau, Rainer · J Pediatr · 2002

case_series · Level IV

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Abstract

We report an estimated prevalence of precocious puberty of 1 in 5 to 6 girls with Williams syndrome (18.3%). Mean menarcheal age of 86 girls with Williams syndrome was 11.5 +/- 1.7 (+/-SD) years. Distribution of menarcheal age was significantly different from that in normal girls (12.9 +/- 1.1 years; n = 759).

Medical subject headings