Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 12221169.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.
Medical subject headings
- Amygdala
- Apolipoproteins E
- Brain Diseases
- Hippocampus