Massive OxyContin ingestion refractory to naloxone therapy.

Schneir, Aaron B; Vadeboncoeur, Tyler F; Offerman, Steven R; Barry, James D; Ly, Binh T; Williams, Saralyn R; Clark, Richard F · Ann Emerg Med · 2002

case_report · Level V

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Abstract

OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.

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