Treatment of primary limited cutaneous extramammary Paget's disease with topical imiquimod monotherapy: two case reports.
case_report · Level V
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Abstract
We present two cases of primary limited cutaneous perineal and genital extramammary Paget's disease (EMPD) that were successfully treated with imiquimod 5% cream. Clinical and histologic cure was confirmed after 7.5 to 12 weeks of monotherapy. Treatment-associated morbidity is minimal compared with more invasive therapies, and self-application by the patient improves convenience and appeal. Imiquimod may offer a minimally invasive and promising therapeutic option for the treatment of limited cutaneous EMPD. The diagnosis and management of EMPD and the current literature regarding imiquimod therapy are reviewed.
Medical subject headings
- Adjuvants, Immunologic
- Aminoquinolines
- Interferon Inducers
- Paget Disease, Extramammary
- Skin Neoplasms