Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.
case_report · Level V
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Abstract
The authors report a patient with severe secondary progressive MS who responded to mitoxantrone but developed a fatal acute myeloblastic leukemia 15 months after completion of mitoxantrone therapy. Therapy-related acute leukemia (TRAL) in relation with mitoxantrone is rare; this patient was the first case among a cohort of 802 French MS patients treated with mitoxantrone. Nevertheless, this case stresses the need to further evaluate the long-term risk of TRAL in patients with MS who receive mitoxantrone.
Medical subject headings
- Leukemia, Myeloid, Acute
- Mitoxantrone
- Multiple Sclerosis