The effect of propofol on increased superoxide concentration in cultured rat cerebrocortical neurons after stimulation of N-methyl-d-aspartate receptors.
basic_science · Level V
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Abstract
The neuroprotective properties of propofol may be because of its action as an antioxidant. To investigate whether propofol reduces the N-methyl-D-aspartate-induced increase in superoxide anion levels, the fluorescence of dihydroethidium acetoxymethylester, as an indicator for cellular superoxide concentration, was measured in cultured rat forebrain neurons.
Medical subject headings
- Anesthetics, Intravenous
- Cerebral Cortex
- Free Radical Scavengers
- Neurons
- Propofol
- Receptors, N-Methyl-D-Aspartate
- Superoxides