Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher's disease.
case_report · Level V
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- Record sourced from PubMed, PMID 12357022.
- Also identified by PMC identifier 1742495.
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Abstract
A splenectomised patient with Gaucher's disease who developed multiple foci of osteomyelitis and soft tissue abcesses, after a severe episode of group C salmonella sepsis, is described. Aggressive antibiotic treatment and surgical drainage had little effect and the patient's condition continued to deteriorate. With initiation of enzyme replacement therapy (ERT) in addition to specific antibiotic treatment, defervescence and gradual healing occurred. Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher's disease is discussed.
Medical subject headings
- Gaucher Disease
- Glucosylceramidase
- Osteomyelitis
- Salmonella Infections
- Soft Tissue Infections