Structural analysis of the RSC chromatin-remodeling complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 12368485.
- Also identified by PMC identifier 129698.
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Abstract
Electron microscopy of the RSC chromatin-remodeling complex reveals a ring of protein densities around a central cavity. The size and shape of the cavity correspond closely to those of a nucleosome. Results of nuclease protection analysis are consistent with nucleosome binding in the cavity. Such binding could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones.
Medical subject headings
- Chromatin
- DNA-Binding Proteins
- Saccharomyces cerevisiae Proteins
- Transcription Factors