Structures of SET domain proteins: protein lysine methyltransferases make their mark.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 12372294.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Proteins bearing the widely distributed SET domain have been shown to methylate lysine residues in histones and other proteins. In this issue, three-dimensional structures are reported for three very different SET domain-containing proteins. The structures reveal novel folds for several new domains, including SET, and provide early insights into mechanisms of catalysis and molecular recognition in this family of enzymes.
Medical subject headings
- DNA-Binding Proteins
- Drosophila Proteins
- Histone-Lysine N-Methyltransferase
- Nuclear Proteins
- Repressor Proteins
- Transcription Factors