Upward bias in estimation of genetic effects.
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- Record sourced from PubMed, PMID 12386837.
- Also identified by PMC identifier 385094.
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Abstract
Because of the large number of tests for linkage that are performed in genome scans, the naive estimator of the size of a genetic effect in cases of borderline significance can be inflated and lead to unrealistic expectations for successful replication. As a remedy, this report proposes lower confidence limits that account for the multiple comparisons of the genome scan.
Medical subject headings
- Bias
- Confidence Intervals
- Quantitative Trait Loci
- Quantitative Trait, Heritable