Enhancement of use-dependent plasticity by D-amphetamine.

Sawaki, L; Cohen, L G; Classen, J; Davis, B C; Bütefisch, C M · Neurology · 2002

case_series · Level IV

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Abstract

In healthy individuals, motor training can elicit use-dependent plasticity. Here the authors studied six subjects in whom training alone failed to elicit this effect. Administration of a single dose of 10 mg of D-amphetamine preceding training led to use-dependent plasticity in a subgroup of these subjects. Using pharmacologic interventions to enhance the effects of motor training might help rehabilitative efforts in patients in whom training alone fails.

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