Milk supplementation prevents bone loss in postmenopausal Chinese women over 3 years.

Abstract

Previously published results from a 2 year randomized, controlled clinical trial on supplementing the diet of postmenopausal Chinese women with high-calcium milk powder (containing 800 mg of calcium) showed that bone loss, as measured by bone mineral density (BMD), was prevented. To determine whether the effect of calcium supplementation could be sustained, the study was extended for 1 additional year. According to the intention-to-treat analysis, the differences in the rate of bone loss (percentage decrease in control group--percentage decrease in milk supplementation group) in the third year of the study were: total body BMD, 0.23% (95% confidence interval [CI] 0.07%-0.39%); total spine BMD, 0.31% (95% CI - 0.02%-0.65%); and total hip BMD, 0.44% (95% CI 0.19%-0.69%). Analysis by the per-protocol method showed a similar effect size. These results indicate that the effects of milk supplementation in preventing bone loss in postmenopausal Chinese women were sustained after 2 years.