Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension.

Warner, Judith E A; Bernstein, Paul S; Yemelyanov, Alexander; Alder, Stephen C; Farnsworth, Steven T; Digre, Kathleen B · Ann Neurol · 2002

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Abstract

We quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a significantly higher level of vitamin A in the cerebrospinal fluid of some patients with idiopathic intracranial hypertension. Vitamin A toxicity may play a role in the pathogenesis of idiopathic intracranial hypertension.

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