Dueling activities of AIF in cell death versus survival: DNA binding and redox activity.
basic_science · Level V
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Abstract
Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.
Medical subject headings
- Cell Death
- Cell Survival
- DNA
- Flavoproteins
- Membrane Proteins
- Oxidation-Reduction