Regulation of chromatin remodeling by inositol polyphosphates.
basic_science · Level V
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- Record sourced from PubMed, PMID 12434012.
- Also identified by PMC identifier 1458531.
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Abstract
Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.
Medical subject headings
- Chromatin
- Inositol Phosphates
- Nuclear Proteins
- Phosphate Transport Proteins
- Saccharomyces cerevisiae Proteins
- Saccharomycetales
- Transcription, Genetic