Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
case_control · Level III
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- Record sourced from PubMed, PMID 12434020.
- Also identified by PMC identifier 137750.
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Abstract
Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors ( approximately 70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing interactions. Here we show that miR15 and miR16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemias (B-CLL). Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases.
Medical subject headings
- Chromosomes, Human, Pair 13
- Gene Deletion
- Gene Expression Regulation, Leukemic
- Leukemia, Lymphocytic, Chronic, B-Cell
- MicroRNAs
- RNA, Neoplasm